Endocrine Abstracts

Introduction: The changes observed in thyroid ultrasound during pregnancy are related to the nutritional status of iodine, but its association with TSH levels or the presence of thyroid peroxidase antibodies (TPOAb) is unclear.Objective: To compare the relationship between the findings in thyroid ultrasound and thyroid function tests in the first trimester of pregnancy in an iodine sufficient area.Subjects and methods: We conducted...

Introduction: Propylthiouracil is a drug used in the treatment of hyperthyroidism and autoimmunity phenomena have been described as a side effect of its use. Despite anti-neutrophil cytoplasmic antibodies (anca) positivity is frequent in patients treated with propylthiouracil, the occurrence of clinically evident vasculitis is rare.Case report: A 65-year-old woman, diagnosed with hyperthyroidism 2 years ago and treated with propylthiouracil (50+...

Introduction: Obesity as a pro-inflammatory state is associated to increased levels of C-reactive protein (CRP). CPR is considered as a cardiovascular (CV) risk independent marker and is being researched as a predictive atherosclerosis biomarker in obese children. The American Heart Association (AHA) recommends a three classes approach when aiming at CV risk stratification (low <1.0 mg/l; moderate 1.0–3.0 mg/l; and high >3.0 mg/l). These classes were extrapolated ...

Introduction: Treatment satisfaction is simultaneously a cause and consequence of the success of bariatric surgery – not only it is a reflection of the efficacy of treatment, it also enhances weight loss. A questionnaire that evaluates this variable has recently been created and validated by the authors (Post-Bariatric Surgery Satisfaction Questionnaire).Objectives: To identify patients’ expectations regarding bariatric surgery; to identify the...

Introduction: Post-bariatric surgery satisfaction relies on psychosocial and clinical factors. A questionnaire that evaluates this variable has recently been created and validated by the authors (Post-Bariatric Surgery Satisfaction Questionnaire).Objective: To assess the relationship between treatment satisfaction and several demographic and clinical variables.Methods: Patients submitted to bariatric surgery who presented to our Ob...

Long-term sequels of pituitary radiotherapy include hypopituitarism, optic nerve atrophy, sensorineural hearing loss, neurocognitive impairment and second intracranial neoplasms, the meningioma being the most frequent. The cumulative incidence of second cerebral tumours within 20 years of the radiation is 2% and, unlike its primary forms, they show a more aggressive atypical histology, and the age of appearance varies depending on the latency time, which in its turn is proport...

Objective: We investigated the clinical usefulness of thyroid blood flow measurement by colour-flow Doppler ultrasonography in predicting relapse of Graves’ disease (GD).Patients and methods: In 30 euthyroid GD patients, (eight males and 23 females), aged 17–68 years (mean 43.8±12.8), after at least 1 year of treatment with anti-thyroid drug (ATD) and just before its withdrawal, we evaluate with colour-flow Doppler ultrasonography the colo...

Introduction: Thionamides are important drugs in the treatment of hyperthyroidism. Despite that, they can be associated with rare but serious complications, which require drug discontinuation.Case report: Sixty-five-year-old woman with Graves’ disease, treated in 2002 with methimazole and in remission until 2012. Recurrence of Graves’ disease was diagnosed in March 2012 and she was started on propylthiouracil (PTU) 150 mg per day. She presented...

Introduction: Patients with psychotic or depressive disorders have an increased risk of developing metabolic syndrome, not only because of their unhealthy lifestyle (sedentary habits, inadequate diet and smoking) but also because of the negative impact of antipsychotic agents (specially clozapine and olanzapine) on several metabolic features. These include overweight/obesity, dyslipidemia, development of new-onset type 2 diabetes, worsening of pre-existing diabetes and diabeti...

Introduction: Generously supported by IPSEN)-->Treatment with recombinant ST is subject to strict criteria. Differences in the response to therapy based on the maximum level of ST in diagnostic tests (ST ≤5 vs ST >5 ng/ml), could predict whose patients would benefit more from therapy.Purpase: Assess differences in the response to therapy with rST in patients with IDGH.Methods: S...